8-9-EET-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

8(9)-EET

Cat.No.:HY-160431

CASNo.:82864-43-5

分⼦式:C₂₀H₃₂O₃

分⼦量:320.47

作⽤靶点:PPAR

作⽤通路:CellCycle/DNADamage;MetabolicEnzyme/Protease;Vitamin

DRelated/NuclearReceptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性（±）8（9）-EET是肾⽪质中的⼀种主要的细胞⾊素P450（CYP450）代谢产物[1][2]。当其浓度为1微摩尔

时，它能在HEK293细胞中激活PPARα，但以PPARα依赖性和⾮依赖性的⽅式抑制由IL-1β诱导的NF-κB

活性[3]。通过氧消耗和产物⽣成测定法，当其浓度为50微摩尔时，它也是COX-1和COX-2的底物[4]。

REFERENCES

[1].Chacos,N.,Falck,J.R.,Wixtrom,C.,etal.NovelepoxidesformedduringthelivercytochromeP-450oxidationofarachidonicacid.

Biochem.Biophys.Res.Commun.104(3),916-922(1982).

[2].Zhang,J.Y.,Prakash,C.,Yamashita,K.,etal.Regiospecificandenantioselectivemetabolismof8,9-epoxyeicosatrienoicacidby

cyclooxygenase.Biochem.Biophys.Res.Commun.183(1),138-143(1992).

[3].Bystrom,J.,Wray,J.A.,Sugden,M.C.,etal.Endogenousepoxygenasesaremodulatorsofmonocyte/macrophageactivity.PloSOne