哮喘免疫表型.pptVIP

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  • 2025-09-02 发布于江西
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Asthma:

ImmunePhenotypes

AsthmaAsthmaisclinicallydefinedasasyndromewithepisodicwheezing,shortnessofbreath,coughandsputumproductionTheconstantfeaturesareairwayirritability(hyperresponsiveness)andinflammation

Asthma:EpidemiologyBetween150-300millionpatientsworldwide15-25millionintheU.S.MostcommonchronicdiseaseofchildhoodOver500,000E.R.visitsperyear25,000ICUadmissions5-6,000deathsinU.S.Ontheincrease

AllergicAsthma:Pathways

IgEIL-13EosinophilsIL-5IL-13Th2Th1MastCellB-cellIL-4TCRMHCIITLymphocyteAPCCD80CD86CD28GenerationofAllergicAdaptive

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