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Go6983(Standard)

Cat.No.:HY-13689R

CASNo.:133053-19-7

分⼦式:C₂₆H₂₆N₄O₃

分⼦量:442.51

作⽤靶点:PKC

作⽤通路:Epigenetics;TGF-beta/Smad

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Go6983(Standard)是Go6983的分析标准品。本产品⽤于研究及分析应⽤。Go6983是⼀种有效的PKC抑

制剂，能够作⽤于PKCα，PKCβ，PKCγ，PKCδ和PKCζ，IC50值分别为7nM，7nM，6nM，10nM和

60nM。

IC50TargetIC50:7nM(PKCα),7nM(PKCβ),6nM(PKCγ),10nM(PKCδ),60nM(PKCζ)

REFERENCES

[1].GschwendtM,etal.InhibitionofproteinkinaseCmubyvariousinhibitors.Differentiationfromproteinkinasecisoenzymes.FEBSLett,

1996,392(2),77-80.

[2].PetermanEE,etal.G06983exertscardioprotectiveeffectsinmyocardialischemia/reperfusion.JCardiovascPharmacol,2004,43(5),

645-656.

[3].YoungLH,etal.G06983:afastactingproteinkinaseCinhibitorthatattenuatesmyocardialischemia/reperfusioninjury.Cardiovasc

DrugRev,2005,23(3),255-272.

McePdfHeight

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