LVTX-8-生命科学试剂-MCE.pdfVIP

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LVTX-8

Cat.No.:HY-P10988

CASNo.:2197957-07-4

分⼦式:C₁₃₅H₂₂₆N₃₆O₃₁

分⼦量:2849.46

Sequence:Ile-Trp-Leu-Thr-Ala-Leu-Lys-Phe-Leu-Gly-Lys-Asn-Leu-Gly-Ly

s-His-Leu-Ala-Lys-Gln-Gln-Leu-Ser-Lys-Leu

SequenceShortening:IWLTALKFLGKNLGKHLAKQQLSKL

作⽤靶点:Apoptosis;MDM-2/p53;Integrin

作⽤通路:Apoptosis;Cytoskeleton

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LVTX-8是⼀种从Lycosavittata中提取的肽毒素。LVTX-8对肺癌具有强效的抗癌和抗转移活性，且具有强的

细胞毒性。LVTX-8通过P53缺氧通路和整合素信号传导显著诱导细胞凋亡(apoptosis)，并抑制肺癌细胞的增

殖、侵袭和迁移。LVTX-8显著抑制A549/H460异种移植⼩⿏模型中的肿瘤⽣长和转移[1]。

REFERENCES

[1].ZhangP,etal.AnAnti-CancerPeptideLVTX-8InhibitstheProliferationandMigrationofLungTumorCellsbyRegulatingCausal

GenesExpressioninp53-RelatedPathways.Toxins(Basel).2020Jun2;12(6):367.

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