猪肺炎支原体的免疫时机及疫苗的选择.pptxVIP

猪肺炎支原体的免疫时机及疫苗的选择

Mycoplasmahyopneumoniae

猪支原体肺炎(Mycoplasmapneumoniaofswine?MPS?)EnzooticPneumonia(EP)

M.hyoDisease猪支原体肺炎Firstisolatedfrompiglungsin首次在猪肺脏中分离Oneofthemostmonandeconomicallyimportantdiseases最普遍和经济意义重大的疾病之一AplexinteractionbetweenM.hyoandotherbacterialandviralinfections,andpoormanagementandventilation.主要损失是支原体和其它细菌病毒的混合感染、饲养管理不善、通风不良等综合因素所致。123456

OneoftheprimarypathogenscausingPorcineRespiratoryDiseaseComplex(PRDC)引起PRDC的原发病原之一Affectsasmanyas99%ofU.S.herds99％的美国猪群都有感染World-widesignificance世界范围内养猪生产中流行M.hyoDisease

hyodiseaseEconomiceffectsareextremelyvariablebetweenherds.不同猪群的经济影响差异较大Dependentoncostofinputs,priceofpigs,otherdiseases,etc.取决于投入的成本、猪价、其它疾病的情况等。AMOVINGTARGET.

M.hyoDiseaseReducedaveragedailygain(ADG)降低日增重Reducedfeedefficiency(FE)降低饲料报酬Increasedmedicationcosts增加药物成本Increasedcullorlight-weightpigs增加淘汰或低体重的猪Etc.

M.hyoEconomicLossesM.hyodecreasedgrowthrate12.7%anddecreasedfeedefficiencyby13.8%(Pointon,etal,1985)肺炎支原体可降低生长率12.7%和饲料报酬13.8%

Transmissionbetweenpigs:aerosolanddirectcontact猪之间传播途径：空气和直接接触Transmissionbetweenfarms:movementofinfectedpigs猪场之间传播方式：感染猪的移动Aerosolbetweenfarms:Britain~3.2km猪场之间传播距离：3.2公里M.hyodisease

Clinicalsignsinclude:临床症状chroniccough(oftendryornonproductive)慢性咳嗽（通常是干咳）highmorbidityandlowmortality高发病率和低死亡率unevengroupsofpigs猪群内生长不整齐M.hyoDisease

M.hyodisease010203040506PeakprevalenceinFinisherbecauseof:单击此处添加小标题Slowspread传播缓慢单击此处添加小标题在育肥期多发的原因：单击此处添加小标题Increasedanimaldensity养殖密度加大单击此处添加小标题Longincubationperiod：潜伏期长单击此处添加小标题Presenceofotherorganisms其他致病菌的出现单击此处添加小标题

M.hyoPathogenesisM.hyocolonizesciliaoftracheaandbronchi….paralyzingthentangling,splittingandbreakingcilia….reducingnormalfunctionofmucociliaryapparatus.支原体定植在气管和支气管纤毛上，导致纤毛缠绕折断、脱落，从而降低了粘液纤毛的正常功能。

OnlyattachestotracheobronchialciliaAmucosalpathogen

M.hyoPathogenesisThereisalsoevi