MRS2690-disodium-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

MRS2690disodium

Cat.No.:HY-116295A

分⼦式:C₁₅H₂₂N₂Na₂O₁₆P₂S

分⼦量:626.33

作⽤靶点:P2YReceptor;p38MAPK;CalciumChannel

作⽤通路:GPCR/GProtein;MAPK/ERKPathway;Membrane

Transporter/IonChannel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MRS2690disodium是⼀种选择性的P2Y14受体激动剂。MRS2690抑制腺苷酸环化酶活性，从⽽降低细胞内

cAMP⽔平，并介导猪冠状动脉的浓度依赖性⾎管收缩。MRS2690诱导细胞内钙动员，激活P38并刺激RBL-

2H3细胞膜的[35S]GTPγS结合。MRS2690增强抗原(NP-BSA)和C3a诱导的β-⼰糖胺酶(β-Hex)释放。

MRS2690可⽤于缺⾎性⼼脏病的研究[1][2][3][4]。

体外研究MRS2690(0.001-10μM)elicitsconcentration-dependentcontractionsofporcineisolatedcoronaryarteriesat

basaltone(logEC50=6.30M)[1].

MRS2690(0.001-10μM)showsenhancedconcentration-dependentcontractileresponsesinporcine

coronaryarteriespre-treatedwithForskolin(HY-15371)plusU46619(HY-108566)(Rmax=1.77g),which

canbeblockedbytheP2Y14antagonistPPTN(HY-110322A),butnotaffectedbytheP2Y6antagonist

MRS2578(HY-13104)[1].

MRS2690(10μM)significantlyreducesforskolin-inducedVASPphosphorylation(anindica