PROTAC-Bcl-xL-degrader-4-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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PROTACBcl-xLdegrader-4

Cat.No.:HY-176740

CASNo.:2930759-37-6

分⼦式:C₃₉H₃₄N₄O₉

分⼦量:702.71

作⽤靶点:PROTACs;Bcl-2Family;p38MAPK;ReactiveOxygen

Species(ROS);MitochondrialMetabolism;Apoptosis;ERK;

JNK

作⽤通路:PROTAC;Apoptosis;MAPK/ERKPathway;

Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κ

B;StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PROTACBcl-xLdegrader-4(Compound2-38-III)是⼀种Bcl-xLPROTAC降解剂。PROTACBcl-xLdegrader-4

对HepG2细胞和HUVEC细胞具有强⼤的抗肿瘤活性。PROTACBcl-xLdegrader-4通过降低线粒体膜电位和

激活MAPK信号通路来诱导细胞凋亡(apoptosis)。PROTACBcl-xLdegrader-4显著抑制异种移植肿瘤⼩⿏模

型中的肿瘤⽣长[1]。粉⾊：MAPKligand(HY-176741)；蓝⾊：CRBNligaseligand(HY-10984)；⿊⾊：

linker(HY-W017440)

IC50TargetBcl-2Bcl-xL

REFERENCES

[1].SunG,etal.Protacsynthesizedonthebasisofazaflavonoid