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(±)-Dehydroaltenusin

Cat.No.:HY-100513

CASNo.:34279-44-2

分⼦式:C₁₅H₁₂O₆

分⼦量:288.25

作⽤靶点:DNA/RNASynthesis;Apoptosis;Antibiotic

作⽤通路:CellCycle/DNADamage;Apoptosis;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(±)-Dehydroaltenusin是⼀种抗⽣素，是⼀种选择性真核⽣物DNA聚合酶α(polα)抑制剂，其IC50为

0.68μM。(±)-Dehydroaltenusin可以从真菌Alternariatenuis中分离得到。(±)-Dehydroaltenusin竞争性

地抑制DNA模板引物的活性(Ki:0.23μM)，并且⾮竞争性地抑制2-脱氧核糖核苷5-三磷酸底物的活性(Ki:

0.18μM)。(±)-Dehydroaltenusin可诱导癌细胞S期周期停滞和细胞凋亡(apoptosis)。(±)-

Dehydroaltenusin可⽤于⼈类腺癌等癌症研究[1]。

REFERENCES

[1].MizushinaY,etal.DehydroaltenusinisaspecificinhibitorofmammalianDNApolymeraseα.ExpertOpinInvestigDrugs.2011

Nov;20(11):1523-34.

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