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鲁索替尼对骨髓纤维化患者生存期影响分析.pdfVIP

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  • 2025-10-23 发布于北京
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鲁索替尼对骨髓纤维化患者生存期影响分析.pdf

    Doesruxolitinibprolongthesurvivalofpatientswithmyelofibrosis?

    12

    FranciscoCervantesandArturoPereira

    1´

    HematologyDepartment,HospitalClınic,Institutd’InvestigacionsBiome`diquesAugustPiiSunyer,UniversityofBarcelona,Barcelona,Spain;and

    2´

    HemotherapyDepartment,HospitalClınic,Barcelona,Spain

    cytoreductivedrugssuchashydroxyurea,splenicradiation,and

    4

    Casepresentationsplenectomy.Theintroductionofruxolitinibhaschangedthe

    therapeuticscenarioofMF.

    A73-year-oldmanwasdiagnosedwithprimarymyelofibrosis(PMF)RuxolitinibistheonlyJAKinhibitorapprovedforthetreatmentof

    afterthealdiscoveryofabnormalitiesinabloodtestperformedpatientswithMF.Asallagentsofthisclass,thedrugmainlyinhibits

    forthecontrolofdiaesmellitus.Thepatientwasasymptomatic.ThedysregulatedJAK-STATsignaling,presentinallMFpatients

    spleenwaspalpableat6cmbelowtheleftcostalmargin.Hemoglo-irrespectiveoftheirJAK2mutationalstatus,butitisnotselective

    binwas10.9g/dL;whitebloodcellcountwas13.29forthemutatedJAK2,whichexinsitsefficacyinbothJAK2-

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