3R-5R-3-5-Dihydroxy-1-7-bis-3-4-dihydroxyphenyl-heptane-3-O-β-D-glucopyranoside-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane3-O-β-D-

glucopyranoside

Cat.No.:HY-N16637

CASNo.:408324-05-0

分⼦式:C₂₅H₃₄O₁₁

分⼦量:510.53

作⽤靶点:NF-κB;PPAR

作⽤通路:NF-κB;CellCycle/DNADamage;MetabolicEnzyme/Protease;

VitaminDRelated/NuclearReceptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane3-O-β-D-glucopyranoside是⼀种从Tacca

plantaginea中分离的⼆芳基庚烷苷类化合物。(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane

3-O-β-D-glucopyranoside显著抑制TNF-α诱导的NF-κB转录活性(IC50=9.4μM)。(3R,5R)-3,5-

Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane3-O-β-D-glucopyranoside显著激活PPAR转录活性(EC50

=9.9μM)并且对PPARβ(δ)有特异性激活作⽤(EC50=23.1μM)。(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-

dihydroxyphenyl)heptane3-O-β-D-glucopyranoside在测试浓度下对细胞⽆毒性。(3R,5R)-3,5-Dihydroxy-

1,7-bis(3,4-dihydroxyphenyl)heptane3-O-β-D-glucopyranoside可⽤于炎症性疾病的研究[