3-6-Diaminoacridine-sulfate-生命科学试剂-MCE.pdfVIP

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3,6-Diaminoacridinesulfate

Cat.No.:HY-W197393

CASNo.:553-30-0

分⼦式:C₁₃H₁₃N₃O₄S

分⼦量:307.33

作⽤靶点:Bacterial;FluorescentDye;PotassiumChannel;DNA/RNA

Synthesis

作⽤通路:Anti-infection;Others;MembraneTransporter/IonChannel;

CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Proflavinesulfate是⼀种多功能的吖啶类化合物。3,6-Diaminoacridine是⼀种吖啶染料，也是⼀种DNA嵌⼊

剂。Proflavinesulfate是⼀种强效⼴谱的抗菌剂，其机制是通过嵌⼊细菌DNA，⼲扰复制和转录，导致细菌

裂解。3,6-Diaminoacridinesulfate是⼀种Kir3.2钾通道阻滞剂，可⽤于研究唐⽒综合征的神经表型。3,6-

Diaminoacridinesulfate可穿透⽪肤⾓质层，在细胞核中积累，长期暴露可能诱发⽪肤癌或其他恶性肿瘤。

REFERENCES

[1].MansourK.Gatasheh,etal.ProflavineanacridineDNAintercalatingagentandstrongantimicrobialpossessingpotentialpropertiesof

carcinogen.KarbalaInternationalJournalofModernScience.2017Dec,3(4):272-278.

[2].HitoshiKawada,etal.IsolationofproflavineasablockerofGprotein-gatedinwardrectifierpotassiumchannelsbyacellgrowth-bas