JAK2-IN-15-生命科学试剂-MCE.pdfVIP

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JAK2-IN-15

Cat.No.:HY-178936

CASNo.:3094174-82-7

分⼦式:C₂₉H₃₅N₅O₄

分⼦量:517.62

作⽤靶点:JAK;STAT

作⽤通路:Epigenetics;JAK/STATSignaling;ProteinTyrosine

Kinase/RTK;StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性JAK2-IN-15是⼀种⼝服有效的强效选择性JAK2抑制剂(IC50=1.17nM)。JAK2-IN-15可抑制AK2-STAT信号

通路。在重组⼈促红素(rhEPO)诱导的⼩⿏模型中，JAK2-IN-15可显著改善⾎细胞⽐容和脾肿⼤等关键病理指

标。JAK2-IN-15可⽤于真性红细胞增多症(PV)的研究[1]。

IC50TargetJAK2

1.17nM(IC50)

体外研究JAK2-IN-15(Compound2)exhibitspotentJAK2inhibition(IC50=1.17nM)[1].

JAK2-IN-15(72h)effectivelyinhibitstheproliferationofHEL(IC50=1.88μM)andSET-2(IC50=9.56μM)

cellscarryingtheJAK2V617Fmutation[1].

JAK2-IN-15(0.3-10μM,72h)exhibitssignificantantiproliferativeactivitiesagainstHELandSET-2cellswith

JAK2V617FmutantbyinhibitingtheJAK2-STATsignalingpathwayinadose-dependentmanner[1].

JAK2-IN-15(100μM)inhibitsonly17wild-typekinases,exhibitingstrongselectivity[1].

WesternBlotAnalysis[1]

CellLine:HEL92.