2024+ISPN循证临床实践指南：尿路感染和原发性膀胱输尿管反流的管理.pdfVIP

PediatricNephrology(2024)39:1639–1668

/10.1007/s00467-023-06173-9

GUIDELINES

Evidence‑basedclinicalpracticeguidelinefor

managementof

urinary

tractinfectionand

primaryvesicouretericrefux

112134

Pankaj

Hari

·Jitendra

Meena

·Manish

Kumar

·Aditi

Sinha

·Ranjeet

W.

Thergaonkar

·Arpana

Iyengar

·

154671

Priyanka

Khandelwal

·Sudha

Ekambaram

·Priya

Pais

·Jyoti

Sharma

·Madhuri

Kanitkar

·Arvind

Bagga

·

onbehalfofIndianSocietyofPediatricNephrology

Received:25June2023/Revised:27August2023/Accepted:17September2023/Publishedonline:28October2023

©TheAuthor(s),underexclusivelicencetoInternationalPediatricNephrologyAssociation2023

Abstract

Wepresentupdated,evidence-basedclinicalpracticeguidelinesfromtheIndianSocietyofPediatricNephrology(ISPN)

forthemanagementofurinarytractinfection(UTI)andprimaryvesicouretericrefux(VUR)inchildren.Theseguidelines

conformtointernationalstandards;InstituteofMedicineandAGREEchecklistswereusedtoensuretransparency,rigor,and

thoroughnessintheguidelinedevelopment.Inviewoftherobustmethodology,theseguidelinesareapplicablegloballyfor

themanagementofUTIandVUR.Seventeenrecommendationsand18clinicalpracticepointshavebeenformulated.Someof

4

thekeyrecommendationsandpracticepointsareasfollows.Urineculturewith10colonyformingunits/mLisconsidered

signifcantforthediagnosisofUTIinaninfantiftheclinicalsuspicionisstrong.Urineleukocyteesteraseandnitritecanbe

usedasanalternativescreeningtesttourinemicr