磁共振多序列定量分析肺结节良恶性诊断中的应用与进展.pdfVIP

分子影像学杂志,2025,48(5):655-660doi10.12122/j.issn.1674-4500.2025.05.20·655·

磁共振多序列定量分析肺结节良恶性诊断中的应用与进展磁共振多序列定量分析肺结节良恶性诊断中的应用与进展

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刘佳明，李海龙，龙志山，刘蓉辉，陈英敏

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河北北方学院研究生院，河北张家口075000；河北省人民医院医学影像科，河北石家庄050051

摘要：磁共振技术安全、无辐射，已广泛全身应用，MRI多序列多参数联合成像打破了单一成像的限制，可以通过扩散加权成像、

体素内不相干运动、动态对比增强MRI、磁共振波谱等技术定量分析，反映病变弥散、灌注及代谢的信息，从分子层面对孤立性

肺结节的良恶性进行鉴别评估，多参数联合成像显著提高了单一成像的敏感度及特异度，优于单一参数成像，并且能进一步分

析MRI在肺癌病理类型分型中具有的应用潜力。MRI多参数联合成像有望提升肺结节的早期诊断率和特异度，为个体化治疗

提供更可靠的依据。

关键词：磁共振成像技术；孤立性肺结节；肺癌；定量分析

Applicationandprogressinthediagnosisofbenignandmalignantpulmonarynodules

bymulti-sequencequantitativeanalysisofmagneticresonance

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LIUJiaming,LIHailong,LONGZhishan,LIURonghui,CHENYingmin

1GraduateSchoolofHebeiNorthUniversity,Zhangjiakou075000,China;2DepartmentofMedicalImaging,HebeiGeneralHospital,

Shijiazhuang050051,China

Abstract:Magneticresonancetechnologyissafeandradiation-free,andhasbeenwidelyusedinthewholebody.Multi-

sequenceandmulti-parametercombinedMRIimagingbreaksthelimitationofsingleimaging,andcanreflecttheinformation

oflesiondiffusion,perfusionandmetabolismthroughquantitativeanalysisbyDWI,IVIM,DCE-MRI,MRSAndother

technologies,soastodifferentiateandevaluatethebenignandmalignantofisolatedpulmonarynodulesfromthemolecular

level.Multi-parametercombinedimagingsignificantlyimprovedthesensitivityandspecificityofsingleimaging,whichis

superiortosingle-parameterimaging.Additionally,itdemonstratespotentialforfurtheranalyzingpathologicaltypingoflung

cancer.MRImulti-parametercombinedi