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CoronaryAtheroscleroticHeartDiseases
AffiliatedHospitalofJiningMedicalCollege
Dept.ofCardiacCareUnit
GuoxiaDongdong.
1/17/20262
ContentsAtherosclerosisStableAnginaPectorisAcuteCoronarySyndromeUAandNSTEMIAMI(STEMI)1/17/20263
Self-studyVariantAnginaCardiacSyndromeXSilentMyocardialIschemiaMyocardialBridging1/17/20264
WhatIsAtherosclerosis?Atherosclerosisisthedescriptivetermforthickenedandhardenedlesionsofthemediumandlargemuscularandelasticarteries.1/17/20265
WhatIsCoronaryHeartDisease?1/17/20266
CoronaryheartdiseaseatherosclerosisCoronarystenosiscoronaryspasmMyocardialischemia,necrosisIschemicheartdisease1/17/20267
1/17/20268
Atherosclerosis1/17/20269
FoamcellFattysteakatheromatousplaquerupturedplaquesFibrousplaqueEndothelialdamagefirstdecadeThirddecadeForthdecadeAdaptedfromStaryHCetal.Circulation1995;92:1355-1374.mediumdamage1/17/202610
Whatdamagedoesatherosclerosiscause?
1/17/202611
CommonlocationCoronaryHeartDiseaseCarotidArteryDiseasePeripheralArterialDiseaseChronicKidneyDisease1/17/202612
Howdoesatherosclerosisstartandprogress?1/17/202613
ElevatedlevelsofcholesterolandtriglyceridesinthebloodHighbloodpressureCigarettesmoking1/17/202614
BiologicalprocessesAccumulationofintimalcellssmoothmusclecellsMacrophagesT-lymphocytes1/17/202615
BiologicalprocessesProliferatedconnectivetissuematrixcollagenelasticfibersproteoglycans1/17/202616
Biologicalprocesses3.Accumulationoflipid1/17/202617
Atherosclerosis-Hypothesis
HypothesisoflipoproteininfiltrationAggregationofplateletsandthrombosisClonaltheoryTheresponse-to-injuryhypothesis1/17/202618
Highbloodpressure,bacterium,virus,toxin,ox-LDL,immunefactor,vasoactivesubstance.Plateletsareactivated,adhesionandaggregationofplatelets.Lipidoses,growthfactor,proliferationofsmoothmuclecells,collagen,lipolyticenzyme.Response-to-injury
1/17/202619
Pathologyandpathophysiology
Fattys
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