基于大语言模型和量子计算开发沙门氏菌耐药性预测平台（英文）.docxVIP

研究报告

PAGE

1-

基于大语言模型和量子计算开发沙门氏菌耐药性预测平台（英文）

一、Introduction

1.BackgroundofSalmonellaResistance

Salmonellaresistanceisasignificantpublichealthconcernthatposesamajorthreattoglobalfoodsafetyandhumanhealth.Salmonellaisagenusofbacteriathatcancausefoodborneillnesses,leadingtosymptomssuchasdiarrhea,fever,andabdominalcramps.Despitetheavailabilityofantibiotics,theprevalenceofantibiotic-resistantSalmonellastrainshasbeenontherise,makingitincreasinglydifficulttotreatinfectionseffectively.TheWorldHealthOrganization(WHO)hasidentifiedantibioticresistanceasoneofthegreatestthreatstoglobalhealth,withestimatessuggestingthatitcouldcause10milliondeathsannuallyby2050ifleftunchecked.

Theemergenceandspreadofantibiotic-resistantSalmonellastrainsareprimarilydrivenbytheoveruseandmisuseofantibioticsinbothhumanandveterinarymedicine.Inagriculture,antibioticsareoftenusedprophylacticallytopromotegrowthandpreventdiseaseinlivestock,whichcanleadtothedevelopmentofresistantbacteriathatcanbetransmittedtohumansthroughthefoodchain.Inhumanmedicine,inappropriateprescribingpractices,suchastheuseofbroad-spectrumantibioticsforviralinfections,contributetothedevelopmentofresistance.AccordingtotheCentersforDiseaseControlandPrevention(CDC),approximately2.8millionantibiotic-resistantinfectionsoccurintheUnitedStateseachyear,resultingin35,000deaths.

TheproblemofSalmonellaresistanceisfurthercompoundedbythelimitednumberofnewantibioticsbeingdeveloped.Thedevelopmentofnewantibioticsisalengthyandexpensiveprocess,andthefinancialincentivesforpharmaceuticalcompaniestoinvestinantibioticresearchhavediminishedduetothelowlikelihoodofrecoupingcostsfromsales.Thishasledtoasituationwherethecurrentarsenalofantibioticsisincreasinglyineffectiveagainstmanybact