Rac-SCH-563705-Standard-生命科学试剂-MCE.pdfVIP

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(Rac)-SCH563705(Standard)

Cat.No.:HY-10011BR

CASNo.:2701435-64-3

分⼦式:C₂₃H₂₇N₃O₅

分⼦量:425.48

作⽤靶点:CXCR;ReferenceStandards

作⽤通路:GPCR/GProtein;Immunology/Inflammation;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(Rac)-SCH563705(Standard)是(Rac)-SCH563705(HY-10011B)的分析标准品。本产品⽤于研究及分析应⽤

。(Rac)-SCH563705是SCH563705(HY-10011)的外消旋混合物。SCH563705(compound16)是⼀种有效

的，可⼝服的CXCR2和CXCR1拮抗剂，IC50值分别为1.3nM和7.3nM，Ki

REFERENCES

[1].MinSH,etal.PharmacologicaltargetingrevealsdistinctrolesforCXCR2/CXCR1andCCR2inamousemodelofarthritis[J].

Biochemicalandbiophysicalresearchcommunications,2010,391(1):1080-1086.

[2].ChaoJ,etal.C(4)-alkylsubstitutedfuranylcyclobutenedionesaspotent,orallybioavailableCXCR2andCXCR1receptor

antagonists[J].Bioorganicmedicinalchemistryletters,2007,17(13):3778-3783.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.