微电子技术论文7511661.pdfVIP

2434IEEETRANSACTIONSONNUCLEARSCIENCE,VOL.63,NO.5,OCTOBER2016

IterativeStructuralandFunctionalSynergistic

ResolutionRecovery(iSFS-RR)AppliedtoPET-MR

ImagesinEpilepsy

J.Silva-Rodríguez,J.Cortés,X.Rodríguez-Osorio,J.López-Urdaneta,J.Pardo-Montero,

P.Aguiar,andC.Tsoumpas

Abstract—StructuralFunctionalSynergisticResolutionI.INTRODUCTION

Recovery(SFS-RR)isatechniquethatusessupplementary

structuralinformationfromMRorCTtoimprovethespatialPOSITRONemissiontomography(PET)isanon-invasive

resolutionofPETorSPECTimages.Thiswavelet-basedmethodimagingtechniquethatvisualizesthedistributionofdif-

mayhaveapotentialimpactontheclinicaldecision-makingofferentradiotracersinthebody,providingfunctionalandmolec-

brainfocaldisorderssuchasrefractoryepilepsy,sinceitcanularinformationontissue.PETiswidelyusedinneurologyfor

produceimageswithbetterquantitativeaccuracyandenhanced

invivoexaminationofbrainfunction,allowingthequantifica-

detectability.Inthiswork,amethodfortheiterativeapplicationof

SFS-RR(iSFS-RR)wasfirstlydevelopedandoptimizedintermstionofcerebralbloodflow,glucosemetabolism,receptorbind-

ofconvergenceandinputvoxelsize,andthecorrectedimagesingandmanyotherphysiologicalparameters[1].PEThasbeen

wereusedforthediagnosisof18patientswithrefractoryepilepsy.provenavaluabletoolont