微电子技术论文7444212.pdfVIP

2452IEEETRANSACTIONSONNUCLEARSCIENCE,VOL.63,NO.5,OCTOBER2016

TissueProbability-BasedAttenuationCorrectionfor

BrainPET/MRbyUsingSPM8

J.Teuho,J.Linden,J.Johansson,J.Tuisku,T.Tuokkola,andM.Teräs,Member,IEEE

Abstract—Boneattenuationremainsamethodologicalchallengetransmission-basedattenuation(TXAC)canbeconsideredas

inhybridPET/MR,asboneishardtovisualizeviamagneticthegoldstandardmethodsforPETattenuationcorrection[2],

resonanceimaging(MRI).Therefore,novelmethodsfortaking[8].BothCTACandTXACallowdirectmeasurementoftheat-

intoaccountboneattenuationinMR-basedattenuationcorrection

(MRAC)areneeded.Inthisstudy,weproposeatissue-proba-tenuationsinogramandrecoveryofthecorresponding-map

bilitybasedattenuationcorrection(TPB-AC),whichemploystheeitherbypiecewiselinearconversionofCTHUvaluesoraro-

commonlyavailableneurologicaltoolboxSPM8,toderiveasub-tatingpointsource[10],[15],[25].However,thesemethodsre-

ject-specific-mapbysegmentationofT1-weightedMRimages.quireanadditionalCTACorTXACscanandincreasethera-

Theprocedurestoderivea-maprepresentingsofttissue,airand

diationburdenofthesubjectiftheyaretobeusedinsteadof

bonefromtheNewSegmentfunctioninSPM8andMATLABare

described.VisualandquantitativecomparisonsagainstCT-basedMRAC.

attenuationcorrection(CTAC)datawereperformedusingtwoTherearetwomethodologicalfactorswhichlimittheaccu-

-values(cmandcm)forbone.ResultsracyofMRACcomparedtoCTACorTXAC.First,nodirect

showimprovementofvisualqualityandquantitativeaccuracytransformationfromMRsignalintensitiestoattenuationcoeffi-

ofpositronemissiontomography(PET)imageswhenTPB-AC

-mapisusedinPET/MRimagereconstruction.Underestimationcientsofphotonsexists.Thus,thevoxelsinanMRimageneed

inPETimageswasdecreasedbyanaverageofperc