分子受体 NKBB 增强 GPC3 CAR-T 细胞的持久性和抗肝细胞癌活性.pdfVIP

PharmacologicalResearch212(2025)107619

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PharmacologicalResearch

journalhomepage:/locate/yphrs

ThemolecularreceptorNKBBenhancesthepersistenceand

anti-hepatocellularcarcinomaactivityofGPC3CAR-Tcells

a,b,d,1a,b,1hfd

MinghaoSui,TiantianLiu,XuanliSon,JiLi,HanDin,YuqianLiu,

XinyuWandidcea,c,*

,HuiminLiu,YuchanXue,JianniQi,MiaoZhan,SongboZhao,

QiangZhua,b,d,*

aShandongProvincialHospital,CheelooCollegeofMedicine,ShandongUniversity,Jinan,Shandong250021,China

bDepartmentofInfectiousDisease,ShandongProvincialHospitalAffiliatedtoShandongFirstMedicalUniversity,Jinan,Shandong250021,China

cDepartmentofCentralLaboratory,ShandongProvincialHospitalAffiliatedtoShandongFirstMedicalUniversity,Jinan,Shandong250021,China

dDepartmentofGastroenterology,ShandongProvincialHospitalAffiliatedtoShandongFirstMedicalUniversity,Jinan,Shandong250021,China

eDepartmentofRadiology,ShandongProvincialHospitalAffiliatedtoShandongFirstMedicalUniversity,Jinan,Shandong250021,China

fDepartmentofSpleenandstomachHepatology,DigestiveCenter,theSecondAffiliatedHospitalofShandongUniversityofTraditionalChineseMedicine,Jinan,

Shandong250001,China

QiluHospitalof