单基因遗传病高级遗传.pptVIP

单基因遗传病高级遗传演示文稿;优选单基因遗传病高级遗传;Multifactorial(common)

Variantsingenescausingalterationoffunction

“Environmental”influencesactonageneticpredispositiontoproducealiabilitytoadisease.

Oneormoreorgansystemaffected.

Personaffectedifliabilityaboveathreshold.

Singlegene(1%liveborn)

Mutationsinsinglegenes(oftencausinglossoffunction)

Dominant/recessivepedigreepatterns(Mendelianinheritance).

Canaffectstructuralproteins,enzymes,receptors,transcriptionfactors.

Chromosomal(0.6%liveborn)

Thousandsofgenesmaybeinvolved.

Mult