蛋白质降解与修饰理论与实验.pptxVIP

蛋白质降解和修饰

旳理论与试验

生化与分子生物学技术与原理

（华东师范大学硕士课程）

李晓涛教授

2023年12月4日;Overview;Proteinsconstituteessentialcomponentsofcells;Lifecycleofproteins;TheProteinDegradationSystemsinCells;The26Sproteasomeisamultisubunitcomplex,consistingofthe20Scatalyticparticleandthe19Sregulatoryparticle,andselectivelydegradesubiquitinatedproteinsinthepresenceofATP.

Uponimmuneresponses,cellsgeneratespecialtypesofproteasomes,immunoproteasomes,whichpossessdistinctregulatoryparticle(11S)andcatalyticparticle(withdifferentcatalyticsubunits),formoreefficientanti