基于流感序列构建氨基酸位点相关矩阵研究.pptxVIP

BackgroundAsweallknow,manydiseasesgetmoreandmoredeleteriouswhilespreadingwidelyandrapidly,suchasinfluenzaandHIV.Hencethedesignofvaccineisimportant,andinthisprojectwetakeinfluenzaforexampletoillustratehowtohelptodesignthevaccinebystatisticalanalysismethods.Forainfluenzasequence,theaminoacids(a.a)onsomesitesofitcanmutateinsomeprobabilitywhenthevirusgetsintothebody,whichbringsoutmoredifficultytothedesignofthevaccine.Indeed,therearesomepairsofsitesonwhichtherespectivea.awillchangesimultaneously,while