慢性心衰治疗研究的新进展.pptVIP

****一*伊伐布雷定进入If通道孔洞，与通道内部的结合位点偶联伊伐布雷定与其它减慢心率药物不同，对If通道的抑制作用不仅是电压依赖性的，而且具有电流依赖性Intheory,therearefourwaysofreducingtheheartsinusrate:ByprolongingtheactionpotentialrepolarizationtimeByreducingmaximaldiastolicpotential(moreelectronegativepotential)ByshiftingthethresholdpotentialtoamorepositivelevelByslowingtherateofdiastolicdepolarization ThisstudyshowsthatProcoralanonlyactsbyreducingtheslopeofdiastolicdepolarizationwithoutsignificantchangesinmaximaldiastolicpotentialIvabradinespecificallyblocksf-channelsinaconcentrat