(8.2.1)--2.HLA分子结构及分布.ppt

HLA分子;;;HLAⅠ类分子;HLAⅠ类分子;VariabilityintheaminoacidsequencesofallelicclassIHLAmolecules;HLAⅡ类分子;HLAⅡ类分子;MHC与抗原肽的相互作用;MHC与抗原肽的相互作用;ConformationofpeptidesboundtoclassIMHCmolecules.

Schematicdiagramdepicting,inasideview,theconformationalvarianceinMHCclassI-boundpeptidesofdifferentlengths.Longerpeptidesbulgeinthemiddle,presumablyinteractingmorewithTCR,whereasshorterpeptideslayflatinthegroove.ContactwiththeMHCmoleculeisbyhydrogenbondstoanchorresidues2and/or3and9.;TCR识别抗原肽-MHC复合物;抗原肽1;;HLAⅠ类分子由α链和β2m组成，肽结合结构域为α1+α2，