如何在顶级科学杂志上发表论文.pdfVIP

新视野系列研究生课程：科技论文的构思、撰写和发表 生物医学世纪讲坛 特邀报告： How to Publish Your Papers in the Top Scientific Journals 鲁白教授 What Is a First-Class Paper? • Major advance in a classic field 干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用 • New techniques and methods that can be widely used 人类基因组研究中的自动测序技术 , PCR, Patch clamp • Discoveries with obvious practical implications AIDS virus receptor 的发现, 老年痴呆症基因的发现 • Conceptual breakthrough, novel ideas 神经营养因子可以促进学习记忆 • Challenge to traditional views, break dogma 脑内有可分裂的神经干细胞，打破了传统观念 • Opening up new area, cross board “细胞凋亡”现象的发现, 开辟了新的科研领域 What Is a Mediocre Paper? • Horizontal growth I made the discovery in rats, you find the same in cat. • Filling gaps EGF activates JNK which is known to induce c-Jun expression. You show that EFG enhances c-Jun expression. • Working out details I found NO induces the production of cGMP, you work out dose response and time course. • Support existing idea, “me too” EGF-R endocytosis requires dynamin, PDGF-R too. • Follow up CREB binds to CRE. Working out CRE sequence. • Incomplete study, preliminary How to Read Scientific Papers? • The Gilbert way • Keep these in mind when you read • What is the major question addressed in this paper? • Is this question important and why? • What are the approaches used in this paper, and whether they are adequate for the questions? • What are the novel idea or using innovative approaches? • What is the concept coming out of this paper? • Do the results presented support this new concept? • Weekly reading of CNS titles • Critical, appreciative Cell September 6, 2002: 110 (5) Articles Pages An RNA Thermosensor Controls Expression of Virulence Genes in Listeria