端粒酶系统在眼部疾病中的研究进展.pdf

20 07 8 27 8 ecAdv Ophthalmol Vol. 27N o. 8A ugust 2007 621 晏 颖 周和政 陈 晓 P o g e s s in s tu d y o f te lem e a s e , , s y s tem o f o c u la d is e a s e B lack bu n [ 3] 1989 YA N Y ing, ZHO U HeZ heng, CHEN X iao !K e y w o d s ∀ telom erase; telom ere; ocu lar disease , !A b s t a c t∀ T elomerase sy stem is th e genetic name , DNA of telom erase and telom ere. Becau se it relates inti ( te lom e e binding p otein, TBP) m ately on th e cells# aging an d proliferation an d the DNA 5# 3#TTAGGG dev eloping ofneoplasm, telom erase sy stem h asb ecome a hot p oint of treatment research. A lot of research has , 2~ 15 kbp, , indicated that telom erase sy stem has mi portant effect , up on ey e in cells# aging and proliferation. W e summ a , r ize th e present research of telom erase and telom ere [ 4, 5] [ 6] , B yan and their applications on ocular disease. [ Rec Adv Ophthalmo l 2007; 27(8): 621624] , !∀ R771. 3 !∀ A , DNA !∀ 1003514 1( 2007) 08062 104 , 5# RNA !∀ 端粒; 端粒酶; 眼部疾病 5# DNA !∀ 端粒酶系统是端粒和端粒酶的总称由于其与细胞 衰老增生乃 癌变的关系密切, 端粒酶系统现已成为癌症及 , 其他增生性疾病治疗研究的热点大量研究表明, 端粒酶的 [ 7] DNA L evy 活性与眼部组织的增生细胞的衰老及眼部肿瘤的发生关系 80, 密切在此, 我们就端粒端粒酶研究现状及其与眼科疾病的 关系和应用进展作 一综述 4 000 bp 1 [ 2007; 27( 8) : 621624] 50 bp 15~ 40 bp , , T [ 1] , 1 50~ 200 bp , , 1~ 4 kbp, ∃%, ,