盘Pgp介导阿魏酸钠对大鼠IUGR的保护作用.docVIP

  胎盘 Pgp 介导阿魏酸钠对大鼠 IUGR 的保护 作用# 鄢友娥* 5 10 （武汉大学基础医学院药理学系 武汉 430071） 摘要：探讨阿魏酸钠对大鼠 IUGR 的保护作用及机制。方法：孕鼠分为正常对照组、IUGR 模型对照组、SF 小、大剂量(25、50 mg· kg-1)组。观察胎鼠生长发育指标、胎盘重及 P 糖 蛋白（mdr1 基因）表达情况。结果：与正常对照组相比，烟酒暴露组胎鼠生长发育指标及 胎盘重降低，mdr1a 表达降低。给予阿魏酸钠治疗后，胎鼠生长发育指标、胎盘重及 mdr1a 表达均被逆转。结论：阿魏酸钠对烟酒所致大鼠胎儿宫内发育迟缓有明显的治疗作用，其机 制可能与增强胎盘 P 糖蛋白（mdr1a 基因）表达有关。 关键词：药理学；阿魏酸钠；宫内生长迟缓；胎盘；P 糖蛋白；烟；酒 中图分类号：R96 15 Enhancement of placental P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure YAN youe 20 25 30 35 40 (Department of Pharmacology of Basic Medical College, Wuhan University, Wuhan 430071) Abstract: This study was aimed to explore the therapeutic effect of sodium ferulate (SF) on rats with Intrauterine growth retardation (IUGR), and then to clarify the mechanism of IUGR. Pregnant rats were divided into normal group, tobacco/alcohol exposure group, and tobacco/alcohol + SF groups. Fetal developmental indices, placental weight, and Mdr1 levels were assayed. Results showed exposure to tobacco/alcohol resulted in reduced fetal developmental indices as well as the decreased Mdr1a level. After SF treatment, fetal developmental indices, and placental weight, and mdr1a levels were reversed. Our study indicated SF may be effective in reversing IUGR production, and its underlying mechanism may be due to enhanced placental P-gp expression. Key words: Pharmacology;Sodium ferulate; Intrauterine growth retardation (IUGR); Placenta; P-glycoprotein (P-gp); Tobacco; Alcohol 0 Introduction Tobacco use during pregnancy exerts a toll for the conceptus at all stages of prenatal development. Every child with significant tobacco smoke exposure in utero has probably been adversely affected to some degree[1-2], including intrauterine growth retardation (IUGR). Ample epidemiological evidences demonstrated that IUGR carried an increased risk of prenatal morbidity and mortality, and individuals born with IUGR were at much greater risk of a wide range of