多层螺旋CT 灌注成像在非小细胞肺癌肿瘤血管生成评价中的应用.pdfVIP

118 2011 2 33 2 N ingxiaM ed J, Feb2011, Vol 33, No2 : 1001- 5949(2011) 02- 0118- 02 论 著 CT 闫少宁, 平学军, 刘 云 [] CT(MSCT)(NSCLC) 16 CT 42 NSCLC( /) , M SCT ( BF) ( BV ) (MTT ) ( PS) 42 NSCLC(MVD), NSCLCMVD CT 42 NSCLCMVD BVBFPS NSCLC CT, [] X线计算机; 灌注成像; 微血管密度;肺肿块; NSCLC [] R814. 42 [] Efficacy ofmulti- slice CT perfusion imaging for the evaluation of tumor angiogenesis in patientswith non- small cell lung cancer (NSCLC) YAN Shao- ning, PINGXue-jun, LIU Yun. ( The ffiliatedHospital ofN ingxiaM edicalUniversity, Y inchuan 750004, China) [Abstract] bjective To evaluate efficacy ofmulti- slice CT perfusion mi aging for tumor angiogenesis in patients with non- small cell lung cancer (NSCLC). M ethods 42 patients with peripheralNSCLC (malignant pulmonary nodules ormasses) proved by pathology were studiedwith 16- slice spiralCT perfusion scanning. FourCT perfusion parameters ofNSCLC including blood flow ( BF), blood volume (BV), mean transit tmi e (MTT), and permeability surface ( PS) were recorded. M ircrovessel density (MVD) of tumor in 42 Pathologic specmi ens ofNSCLC were determ ined by mi munohistochemistry staining, and thenMVD ofNSCLC was correlatedwith its CT perfusion parameters. Results The BV, BF and PS of 42 cases ofNSCLC positively correlatedw ithMVD. Conclusion The CT perfusion parameters ofNSCLC can evaluate tumor angiogenesis ofNSCLC. It is a non- invasive and idealway to evaluate tumor angio genesis in living body. [Keywords] X - ray computed tomography; Perf usion mi aging; icrovessel density; Lungmasses; NSCLC , MVD (MVD) 1 , 11 一般资料: 2006 10- 2009 9 [ 1- 2] MVD CT , ,