Parkin RING1结构域突变对其线粒体转位和与PINK1相互作用影响.docVIP

  Parkin RING1 domain mutant impair its mitochondrial translocation and interaction with PINK1 5 10 15 20 25 30 35 40 45 50 YANG Hui1, YANG Ling2, GAO Peiye2, ZUO Ji2, YE Xiaofei2, LIU Wen2** (1. The doctor-patient relationship office, Beijing Shunyi Hospital of China Medical University,101300; 2. Department of Cellular Gentic Medicine, School of Basic Medical Science,Frudan University, 200032) Abstract: In Mutations in Parkin and PTEN-induced putative kinase 1 (PINK1) could cause autosomal recessive forms of Parkinsons disease (PD), but how these mutations trigger mitochondrial dysfunct