血液炎症标记物在诊断小儿急性阑尾炎中意义.pdfVIP

·1154 · 南方医科大学学报（J South Med Univ ） 2012;32(8) 临床研究 血液炎症标记物在诊断小儿急性阑尾炎中的意义 1 2 2 黄党生 ，韩 溟 ，谢 扬 1 2 广东省揭阳市东山区第二人民医院，广东 揭阳 522031 ；汕头大学医学院第二附属医院，广东 汕头 515041 摘要：目的研究血液中炎症标记物在诊断小儿急性阑尾炎（AA）中的意义。方法 收集东山区第二人民医院近4 年51 例4~ 12 岁小儿急性阑尾炎患儿及16例无手术的非特腹痛患儿血样，检测白细胞计数、血清C-反应蛋白、白细胞介素6（IL-6）和肿瘤坏死 因子-α（TNF-α）水平。结果 严重急性阑尾炎患儿（蜂窝织性或坏疸性阑尾炎和阑尾穿孔）白细胞计数、血清C-反应蛋白、IL-6及 TNF-α水平显著高于非特腹痛患儿及单纯性小儿急性阑尾炎。ROC 分析表明，IL-6 和TNF-α用于鉴别诊断严重小儿急性阑尾 炎均优于白细胞计数（P0.05）。结论 IL-6 和TNF-α水平可为临床医师提供辅助诊断信息，选择合适手术时机。 关键词：急性阑尾炎；炎症标记物；白细胞介素6 ；肿瘤坏死因子-α 中图分类号：R574.61 文献标志码：A 文章编号：1673-4254（2012）08-1154-03 doi: 10.3969/j.issn. 1673-4254.2012.08.18 /kcms/detail/44.1627.R1019.008.html Value of blood inflammatory markers in the diagnosis of acute appendicitis in children 1 2 2 HUANG Dangsheng , HAN Ming , XIE Yang 1Second Peoples Hospital of Jieyang Dongshan District, Jieyang 522031, China; 2 Second Hospital Affiliated to Shangtou University Medical College, Shantou 515041, China Abstract: Objective To investigate the value of serum inflammatory markers in the diagnosis of acute appendicitis (AA) in children. Methods Blood samples were collected from 51 children with AA and 16 children with nonsurgical abdominal pain (NSAP) to examine white blood cell count (WBC), serum C-reactive protein (CRP), interleukin-6, and tumor necrosis factor-α (TNF-α). Results WBC count, CRP, IL-6 and TNF-α increased significantly in children with severe AA (phlegmonous or gangrenous, and perforated appendicitis). ROC curves showed that IL-6 or TNF-αhad a greater contribution than WBC count to the diagnosis of severe appendicitis. Conclusion IL-6 and TNF-α can provide complementary information to assist the