The Abnormal High Expression of B Cell Activating Factor Belonging to TNF Superfamily （BAFF） and Its Potential Role in Kidney Transplant Recipients.pdfVIP

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The Abnormal High Expression of B Cell Activating Factor Belonging to TNF Superfamily （BAFF） and Its Potential Role in Kidney Transplant Recipients.pdf

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Cellular Mo1ecularImmunology 465 Article TheAbn0rmalHighExpressi0n0fBCellActiVatingFact0r Bel0n ngt0TNFSuperfamily(BAFF)andItsP0tentialR0lein Kidneyr】[1ransplantRecipients HaiyanXu，XiaozhouHe，，QingLiu，YingdiChen，YibeiZhu，DanShiandXueguangZhang’ B celIactivatingfactorbelongin2t0TNFsuperfamily(BAFF)isacriticalre2ulat0r0fB cellmaturationand survivaI．In thispresentstudy’theexpressiOn characteristic0fIIAFF in kidneytransplantati0n recipientswas investigated，itspOtentialsignilicancewasanalyzedandperipheralblOOd0ff_0IlOw．upkidneytransplantrecipients wasstudied．Fl0w cytOmetricassaVresultssh0wed that，cel1．surfaceBAFFwassi2nificantlVhi2hIV expressed0n peripheralCD3’T lymphocytesin 5yrsgroup0fkidneytransplantrecipients，comparedwithothergroups 0．05)．BAFFexpressioncouIdbef0lundonCD4’TcelJsandCD8十Tcells．TheBAFFmRNA leveIsinperipheraI mon0nuclear cellswere cOnsistentwith the pr0tein levels．HOwever_serum sOluble BAFF levelswere inte卜 individuaUydit1．erentin eachgr0up．StratifiedbyrenalfunctiOn，itwasf_0undthatcell—surfaceBAFFlevelswere si2nificantlyhi2herinth0sewithabn0rmalrenalfuncti0n，comparedwithrecipientswithnormalrenaIfunction O．O5)．ELISAassayresultssh0wedthatexpressionlevels0fceUsurfaceBAFFweresi2nilicantlyc0rrelatedwith anti—HLA I IIant．bOdies．TheseresultsindicatethatBAFFmaybeinvOlvedinthedevel0pmentOf2raft．10ssand innuencesthel0ng—time0utcOmeOfkidneyall0graft，likelVmediatedbVinterferin2withimmunerespOnse．‘ ，．＆ c ，J砌，lD ，．2008；5(6)：465．470． KeyWords：BAFF，expressi0n，renaIa11ograR，rejection IntrOductiOn calcium．modulatorandcvclophi1inHgandinteractor(TACI) andB—ceUmaturationantigen CMA)，sharedwithanother Bcel1activatingfact0rbelongingtoTNFsuperfamilv(BAFF_ TNFligand，aproljferati0n—inducingliga