丙烯酰胺生殖和发育毒性及其生物标志物的研究进展.pdfVIP

5 2 Vol. 5 No. 2 2014 2 Journal of Food Safety and Quality Feb. , 2014 鲁 静, 周 催, 孙 娜, 王 静, 王翠艳, 车会莲* (, 100083) 摘 要: (acrylamide, AA)120 , AA , AA AA , AA ; , AA , , AA AA , AA 关键词: ; ; ; Review of the biomarker research of acrylamide reproductive and developmental toxicity * LU Jing, ZHOU Cui, SUN Na, WANG Jing, WANG Cui-Yan, CHE Hui-Lian (College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China) ABSTRACT: Acrylamide (AA) is primarily generated in starchy food which heated up to 120 . Researches showed that AA had reproductive toxicity, developmental toxicity, neurotoxicity and genetic toxicity to the body. Especially, the reproductive and developmental toxicity of AA attracted a great of attentions gradually. In the research of reproductive toxicity and developmental toxicity of AA, any indexes reflected reproductive system damage could be used as biomarkers of AA reproductive toxicity. As the same, any indexes reflected developmental system damage could also be used as biomarkers of AA developmental toxicity. As more and more biomarkers have been determined, they will play an important role in the risk assessment. Therefore, the evaluation of biomarker has very important signifi