病理学 8年制2版05免疫疾病.pptVIP

Etiology and Pathogenesis progressive fibrosis Microvascular disease Morphology Skin Alimentary Tract Musculoskeletal System Kidneys Lungs Heart extensive subcutaneous fibrosis Vasculitis GIANT-CELL ARTERITIS Giant-cell (temporal) arteritis is the most common form of vasculitis among elderly chronic, typically granulomatous inflammation of large to small-sized arteries principally the temporal arteries Morphology nodular intimal thickening granulomatous inflammation elastic lamina fragmentation GIANT-CELL ARTERITIS POLYARTERITIS NODOSA Polyarteritis nodosa (PAN) is a systemic vasculitis of small or medium-sized muscular arteries typically involving renal and visceral vessels Morphology. segmental transmural necrotizing inflammation of small to medium-sized arteries weakens the arterial wall Impaired perfusion transmural inflammation fibrinoid necrosis thickening of the vessel wall POLYARTERITIS NODOSA THROMBOANGIITIS OBLITERANS Thromboangiitis obliterans (Buerger disease) is a distinctive disease that often leads to vascular insufficiency segmental, thrombosing, acute and chronic inflammation of medium-sized and small arteries tibial and radial arteries Pathogenesis The strong relationship to cigarette smoking Morphology sharply segmental acute and chronic vasculitis of medium-sized and small arteries microabscesses WEGENER GRANULOMATOSIS Acute necrotizing granulomas of the upper respiratory tract Necrotizing or granulomatous vasculitis affecting small to medium-sized vessels Renal disease Morphology. Upper respiratory tract lesions granulomas with geographic patterns of central necrosis vasculitis renal lesions Rejection of Tissue Transplants Mechanisms of Recognition and Rejection of Allografts T Cell-Mediated Reactions Antibody-Mediated Reactions Rejection of Solid organ transplantation (Kidney) Hyperacute Rejection. Acute Rejection. Acute cellular rejection Acute humoral rejection (rejection vasculitis) Chro