CpG ODN联合HBsAg免疫BALB-c小鼠和HBV转基因C57BL-6J小鼠.DOCVIP

临床医学论文-CpG ODN联合HBsAg免疫BALB/c小鼠和HBV转基因C57BL/6J小鼠 【关键词】? 乙型 ??? CpG oligodeoxyribonucleotide with hepatitis B surface antigen (HBsAg) for vaccination in BALB/c and HBVtransgenic mice 　　【Abstract】AIM：? To study the effects of CpG oligodeoxyribonucleotide (ODN) as adjuvant on the immune responses in BALB/c and HBV-transgenic mice with hepatitis B surface antigen (HBsAg). METHODS:?BALB/c and HBV transgenic mice were immunized by multiplesite intramuscular injection with HBsAg and phosphorothioate oligodeoxynucleotides containing two CpG motifs. The HBsAg and antiHBs in serum from immunized mice w