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4/3/2001 P.J.Hines What Is the Purpose of Doing Research? Basic Elements for Basic Research Good Research Is the Key What Is a First-Class Paper/Research? Should your paper go to CNS? What helps: Convincing data Appropriate controls Careful presentation Consideration of all viable alternatives What doesn’t help The minimal publishable unit. Excessive or unfounded speculation Repeat examples of a known phenomenon Insufficient advance over previously published work Invite thorough critique Run your own review process first ask feedback from someone in your own specialty someone in an unrelated specialty a good editor for the English language Assess both research and presentation Common reasons for rejection Belongs in a specialized journal Too small of an advance over previously published work Unconvincing data Observations without interpretations Interpretations without data Is it a good paper or not? what makes a great paper? Astounding work of great value to its own field and/or to the general readership Common problems resulting in rejection of a manuscript too small of an advance not of general interest/ belongs in specialized journal not scientifically convincing, interpretations poorly supported results not well interpreted, poor context Discussion Summary of main findings Papers that support you, but don’t downgrade your novelty Pitfalls and why Significance. Don’t speculate too much The results in the present study may have a number of implications in the cell biology of tyrosine kinase receptors. First, we report the ... To our knowledge, this is the first demonstration for ... Thus, our results suggest a cross-talk between Ca2+ and tyrosine kinase signaling pathways. Second, the present study reveals an important regulatory effect of ... It will be interesting to determine whether ... Finally, we show that ... Xxx ... Taken together, these results suggest a general role of tyrosine kinase in the endocytosis of growth factor receptors. There are
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