ａ干扰素联合甘利欣治疗慢性乙型肝炎疗效观察.DOCVIP

临床医学论文-ａ干扰素联合甘利欣治疗慢性乙型肝炎疗效观察 【摘要】? 目的：观察ａ干扰素联合甘利欣治疗慢性乙型肝炎的疗效。方法：治疗组予ａ干扰素500万U单位，肌注，1次／d×30 d；后改为隔日1次，总疗程为6个月，同时口服甘利欣胶囊150 mg，3次／d，疗程为6个月。对照组采用干扰素，剂量方法同前。治疗前后分别检测ALT、HBV-DNA、HBeAg、抗-HBc。一年后分别测定两组的HBV-DNA、HBeAg复阳率。结果：治疗组治愈率和显效率、ALT复常率、HBV-DNA、HBeAg阴转率及抗-HBc 转阴率均较对照组明显增高；治疗1年后治疗组患者血清HBeAg和HBV-DNA复阳率较对照组明显下降。结论：ａ干扰素联合甘利欣治疗慢性乙肝近期和远期疗效好，复发率低。 【关键词】? α干扰素； 甘利欣； 慢性乙型肝炎 　　Observing Curative Effect of α Interferon Combined with Ganlixin to Treat Chronic Hepatitis B 　　Abstract： Objective: To observe curative effect of α interferon combined with Ganlixin to treat chronic hepatitis B. Method: The treatment group was given α interferon of 5 million U unit for muscle injection for one time/d for 30 days, and then one time every other day for 6 months as a period of treatment, also given Ganlixin capsule 150 mg，3 times／days for 6 months orally taking as a period of treatment; The comparison group uses interferon as above method in same dosage method. The ALT, HBV DNA, HBeAg and anti-HBc are tested for two groups of patients before and after the treatment; the positive recovery rate of HBV DNA、HBeAg is tested in one year separately. Result: The curing rate, evident effect rate, ALT recovery rate, HBV DNA, HBeAg negative changing rate and anti-positive –HBc negative changing rate are higher than that of the comparison group; the positive changing rate of serum HBeAg and HBV DNA is evident lower than the comparison group. Conclusion: The curative effect of treatment for α interferon combined with Ganlixin to treat chronic hepatitis B is better for recent and long period, which is lover recovery rate. 　　Key words:? α Interferon；? Ganlixin；? Chronic hepatitis B??? 　　　 　　乙型肝炎病毒是一种高变异病毒，容易形成变异株，从而给治疗方面带来很大的困难，因而需要积极探讨和寻求一种能提高临床治疗效果的方法和手段。我们自2003年1月至2006年3月应用ａ干扰素联合甘利欣治疗慢性乙型肝炎122例，取得理想的临床效果，现报告如下。 　　1? 资料与方法 　　1．1? 一般资料：依据全国第五次传染病寄生虫病学术会议修订的《病毒性肝炎防治方案》［1］，选择2O03年1月至2006年3月本院传染科患者l22例，其中男88例，女34例，年龄18～52(31.3±8.9)岁，病程平均3.6年。随机分为2组，所有病人均为HBeAg和HBV DNA双阳性，并排除甲、丙、丁、戊型肝炎病毒感染及酒精性肝炎，自身免疫性肝炎，药物中毒