人感染H7N9禽流感研究进展及防控要求.ppt

Somehow point out there are a total of 6 but our analysis is based on censored data up to the point of manuscript submission – also briefly say what happened to the 6th case (ie v similar disposition to the other 5) * age ranged from 2 to 26 years (mean 13 years) four (80%) were male Three were young children All presented with fever, plus some other upper respiratory tract symptoms By contrast with the generally severe clinical picture reported so far for A/H7N9 infection, all five patients had mild to moderate disease and have already recovered Among them, three (60%) were managed only as outpatients without being prescribed antiviral drugs, and RT-PCR result only turned positive after their clinical recovery the other two (40%) were admitted to hospital and subsequently discharged. One patient had pneumonia without requiring intensive care. * * Table 2 shows estimated overall fatality risk and risk of other adverse outcomes. Fatality risk was higher for individuals aged 60 years or older than for younger individuals (p=0·0019; figure 1, table 2). For the 37 individuals who died, median time to death was 11 days (IQR 6–23). For the 65 individuals who recovered, median time to recovery was 18 days (14–29). We estimated that risks of ICU admission (p=0·08) and mechanical ventilation (p=0·0067) were higher for patients aged 60 years or older than for younger patients (figure 2, table 2). We recorded some evidence that disease progressed or resolved faster in patients younger than 60 years than in older individuals (fi gures1, 2), but the small sample size meant that we did not have sufficient statistical power to warrant further investigation. * * Because H7N9 is still an avian influenza virus, turkey red blood cells were used in the HI assay as previous described. Among the 45 hospitalized patients with laboratory-confirmed H7N9 virus infection, 38 survived, and 25 (65.8%, 25/38) patients who survived were found to have HI antibody titer of ≥80 for the H7N9 vir