瑞舒伐他汀对急性冠状动脉综合征(ACS)合并心律失常患者炎症和凋亡反应的作用分析2.docVIP

瑞舒伐他汀对急性冠状动脉综合征(ACS)合并心律失常患者炎症和凋亡反应的作用分析 [摘要]目的 探讨瑞舒伐他汀对急性冠状动脉综合征(ACS)合并心律失常患者炎症和凋亡反应的作用。方法 选择于我院诊断的50例单纯性ACS患者与50例ACS合并心律失常患者作为研究对象，两组患者均于每晚睡前服用10mg瑞舒伐他汀进行治疗。对两组治疗前后血脂指标、谷草转氨酶（AST）、谷丙转氨酶（ALT）、同工酶（CK）、血浆vWF（%），治疗前后炎症因子（ sVCAM-1）、白介素-1β（IL-1β）、高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白介素-18（IL-18）进行比较，以及对ACS合并心律失常组治疗前后室性早搏Lown分级与炎症因子的相关性进行分析。结果（1）除LDL-C外，两组治疗前后其他血脂指标、AST、ALT、CK、血浆vWF水平相比，差异均具有统计学意义（P＜0.05）；（2）ACS合并心律失常组治疗前各炎症因子水平均显著高于单纯ACS组治疗前各炎症因子水平（P＜0.05），且两组治疗前后炎症因子水平差异均具有统计学意义（P＜0.05）；（3）ACS合并心律失常患者组治疗前后炎症因子水平随着室性早搏Lown分级的递增而增大。结论 ACS合并心律失常与炎症因子存在正相关性，表明炎症因子可能是ACS患者并发心律失常的重要原因；瑞舒伐他汀具有抗炎以及抗凋亡的作用，将其用于治疗ACS合并心律失常的效果显著，值得在临床上加以推广并应用。 [关键词]瑞舒伐他汀；ACS合并心律失常；炎症因子；凋亡反应；室性早搏Lown分级 Analysis of rosuvastatin for acute coronary syndrome (ACS) patients with arrhythmia response induced inflammation and apoptosis [Abstract] Objective To investigate the rosuvastatin for acute coronary syndrome (ACS) patients with arrhythmia response induced inflammation and apoptosis. Methods To select 50 cases of simple ACS and 50 cases of ACS combined with arrhythmia diagnosed in our hospital as the researching objects, and they were given 10mg rosuvastatin for treatment at bedtime. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), isoenzyme (CK), plasma vWF (%),inflammatory factors (sVCAM-1), interleukin-1β (IL-1β), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin -18 (IL-18) are compared, as well as ACS premature ventricular arrhythmia before and after treatment were compared, and the relationship between Lown classification and inflammatory cytokines correlation was analyzed. Results (1) Except for LDL-C, there were statistical differences of the other lipid parameters, AST, ALT, CK, plasma vWF levels before and after treatment (P 0.05). (2) The inflammatory cytokines of ACS arrhythmia group were significantly higher than those of the ACS group before treatment (P 0.05), and the levels of inflammatory cytokines were statistically significant