布鲁氏菌外膜蛋白研究进展.pdfVIP

380 20 10 5 30 25 5 D isease Su rve illan ce, M ay30, 20 10, V ol25, N o5 综 述 布鲁氏菌外膜蛋白的研究进展 1, 2 2 1 1, 2 胡剑飞 , 崔步云 , 关平原 , 刘志国 : , 3 10 k18 k19 k, Om p10Omp16 Omp 19 2 36 k~ 38 k 3 31 k~ 34 k 25 k ~ 27 k , Om p25 Om p31 3 : ; ; ; : R 5 167 : A : 1003 - 996 1( 20 10) 05- 0380- 10 Progress in research on outer membrane proteins ofB rucella HU J ian fei 12, CU I Bu yun, G UAN P ingyuan , L IU Zh iguo. 1. Inner M o ng o lia Ag riculture U n iver sity, H ohho t 010018, Inner M ongo lia, C hina; 2. Na tio na l Institute fo r C ommunicable D isea se Con tro l and P rev entio n, Chinese C en ter fo r D isea se Con tro l and P reventio n, Bei ing 102206, C hina Corr esp ond ing au thor: CU I Buyun, Em a il: cu ibuyun@ icdc. cn; GUAN P ing yuan, Em a il: gpyum @ yaho o. com . cn Abstract: T he o ute r m em brane o f Brucella spp is m a in ly com po sed o f L ipopo ly saccharide, outer m em brane pro te ins and pho spho lip id. The m a or outer m em brane pro tein s o f Bru ce lla spp. are character ized a s po tential mi m uno gen and pro tec tive antigen s. T hey a re c lassif ied acco rd ing to the ir m o lecular m ass in to three g ro up s, the g roup 1 pro te in s w hich consists o f 10 k, 18 k and 19 k. In th is g roup, Om p10, Om p16 and Om p 19 are lipo pro te ins. 36- 38 k OM Ps are group 2 pro te ins, and 31- 43 k and 25- 27 k OM P s be long to the group 3 pro te in s, Om p25 and Om p31 are c lo se ly re lated to the v irulence and mi m unog en icity o f Bru ce lla. T h is paper w ill summ arize th