实验性肺纤维化大鼠发病过程中肺组织FIZZ1蛋白和mRNA表达的动态变化.pdfVIP

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实验性肺纤维化大鼠发病过程中肺组织FIZZ1蛋白和mRNA表达的动态变化.pdf

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Acta Physiologica Sinica, August 25, 2005, 57 (4): 493-497 493 FIZZ1 mRNA 1 2, * 1 1 1 2 430022 430030 FIZZ1 (found in inflammatory zone 1) (5 mg/kg ) HE Masson FIZZ1 mRNA (1) (7 d)(14~21 d)(28 d)(2) FIZZ1 7 d 14 d 7 d 21 28 d (3) FIZZ1 mRNA 7 d 14 d 21 28 d FIZZ1 mRNA FIZZ1 mRNA Q593; R362; R563.1 Dynamic changes of found in inflammatory zone 1 protein and mRNA expression in the lung with experimental pulmonary fibrosis of the rat 1 2,* 1 1 MA Wan-Li , YE Hong , TAO Xiao-Nan , XIN Jian-Bao 1Pulmonary Laboratory of Ministry of Health of China, Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 2Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Abstract To investigate the role of found in inflammatory zone 1 (FIZZ1) protein in the pathogenesis of experimental pulmonary fibrosis, 48 male Sprague-Dawley rats were randomly divided into two groups, the pulmonary fibrosis group and the control group. Rat pulmonary fibrosis was reproduced by an intratracheal injection of bleomycin (5 mg/kg body weight). Normal saline (1 ml/kg body weight) was given intratracheally injection in the control group. There were 24 rats in each group, and 6 animals were separately killed on the th th th th 7 , 14 , 21 and 28 day after treated with bleomycin