RhoA经基质金属蛋白酶_3_9_省略_心力衰竭大鼠心肌重塑及心功能恶化_佟浩.pdfVIP

C HINESE J OU RNAL OF ANAT OM Y Vol. 31 No. 2 2008 2008 31 2 RhoA -3-9 X 1 2 佟 浩 张 曼 ( 1 , 110001; 2 , 110024) 目的: RhoA Rho ( M MPs) MM P-3M MP-9 方法: ( 12 20 ) Nikon 4 , H-E , RT-P CR RhoA Rho MMP-3MMP-9 结果: 20 12 , , RhoARho MMP-3MM P-9 , RhoA Rho MMP-3MMP-9 结论: RhoA MMP-3MM P-9 , RhoA ; Rho ; ; ; ; RhoA regulates the myocardial remodeling and functional deterioration through X matrix metalloproteinase-3 and 9 1 2 T ong H o , Zh ng M n ( 11 Dep artment of A natomy , College of Basic Medical Science, China Med ical University , S heny ang 110001; 21 Dep artment of Cardiology , Af f iliated Fengtian H osp ital, S henyang Medical College, Shenyang 110024, China) Abstract Obj ective: T o study the rel t ionship betw een the expressions of RhoA , Rho kin se nd m trix met lloprotein se- 3, 9 nd myoc rdi l remodeling nd function l deterior tion in he rt f ilure model r t s. Methods: 20 he rt f ilure r ts nd 10 ge-m tched sh m oper t ion r ts w ere prep red for this experiment. W e detected the gene expressions of RhoA , Rho ki n se nd MMP-3, 9 on myoc rdi l tissue in the he rt f ilure r ts nd in t he sh m oper tion r ts. C rdi c function per meters nd H-E st ining w ere me sured. Res ults: With m yoc rdi l remodeling nd funct ion l deterior tion, the gene expressions of RhoA nd RhoA kin se were incre sed signific nt ly comp red w ith those in sh m group, w hich were posit ive correl ted w ith the expressions of MMP-3 n