乳腺癌组织中CyclinD1及p16蛋白表达的联合检测及其意义.pdfVIP

2006 2 13 3 CH IN J CANCE R PREV TREAT , February 2006, Vol. 13 No. 3 1 临床研究 Cyclin D1p16 1 2 2 周蕾蕾 , 赵俊玲 , 杨金巧 1. 四川省人民医院乳腺科, 四川成都610072 2. 四川大学华西医院普外科, 四川成都610041 Clinical significance of Cyclin D1and p16 expressions inhuman breast cancer tissues 1 2 2 ZH OUL eilei , ZH A OJ unling , YAN G Jinqiao 1. Dep artment of Mammog ram, Sichuan rovincial eop les H osp ital, Cheng du 610072, .R. China 2. Dep artment of General Surg ery , West China H osp ital of Sichuan Univ ersity , Chengd u 610042, .R. China : 探讨乳腺癌中Cyclin D 1 及 [ ABSTRACT] OBJECTIVE: To detect Cyclin D1 and p16 oncopro p16 蛋白表达的相关性及其临床意义 tein expressions in human breast cancer tissues and discuss their clinical : LSAB 法检测 种乳腺组织中Cyclin D1 significance. METHODS: T he expressions of Cyclin D1 and p16 on 及p16 蛋白的表达情况, 结合有关临床资 coprot ein in 62 primary breast cancer tissues, 40 cases breast tis 料, 分析 Cyclin D1 和 p16 蛋白表达异常与 sues near by malignant and 24 cases benign breast disease speci 乳腺癌中重要的临床病理因素的关系 mens, were examed by the immunohistochem ical LSAB technique : 62 例乳腺癌组织中, Cyclin D1 蛋白过度 then the relationship bet ween the overexpressions of Cyclin D1 and 表达占484% , 其表达与乳腺癌组织学分级 p16 and clinicopothological factors w as analysed. RESULTS: The 呈明显正相关, 且 Cyclin D1 蛋白过度表达 overexpression rate of Cyclin D1 w as 484% in breast cancer, 更常见于ERPR 阳性的乳腺癌中乳腺癌 20% in breast tissues near by malignant, rare expression in normal 旁组 织 中 Cyclin D1 蛋白过 度表 达为 breast tissues. The overexpression of Cyclin D1 in breast cancer 200% , 其他几种乳腺组织很 少有 Cyclin tissues show ed positive relationship w ith histological grade, esp