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捅要
目的:探讨失代偿期肝硬化患者胃黏膜中生长激素释放肽(Ghrelin)的表达。
方法:随机选取2009年5月一2012年4月就诊于青岛市市立医院的乙肝后肝硬化患
者47例、慢性乙型肝炎患者18例,同时选取胃镜检查大致正常的健康志愿者19
例作为对照组。采用免疫组化方法检测Ghrelin在胃黏膜中的表达水平。
结果:①肝硬化组患者与对照组相比,胃黏膜内Ghrelin的阳性表达率下降
(仄0.05),幽门螺杆菌(Helicobacter
②慢性乙型肝炎组患者与对照组比较,胃黏膜内Ghrelin的阳性表达率明显下降
(仄0.05),丘pylori感染率升高(少O.05)。③肝硬化组与慢性乙型肝炎组相比,
⑤对照组、慢性乙型肝炎组、肝硬化组、Child-pughA级、Child-pughB级、
Chiid—pugh
尼pylori阴性的相比升高,但各组内两者问的比较差异均无统计学意义(少0.05)。
结论:乙肝后肝硬化患者胃黏膜损伤,导致胃黏膜内Ghrelin的表达减少,推测
Ghrelin可能成为预测肝硬化患者胃黏膜病变程度的指标。碰pylori感染加重胃黏
膜的损伤,建议早期干预治疗肝硬化患者的丘pylori感染。Ghrelin可能具有抵抗
丘pylori感染的作用。
硕士研究生:杜学芳(内科学消化系病)
指导教师:王青教授
关键词:肝硬化;乙型肝炎;生长激素释放肽;幽门螺杆菌
Abstract
To the ofGhrelinin mucosaof
Objectiveinvestigateexpression gastric deconpensated
cirrhosis.
Methods with B-relatedlivercirrhosisand
Forty—sevenpatientshepatitis eighteen
chronicHBV-infectedatour from 2009to 2012were
patients hospitalMay April
enrolledinthis volunteersweretakenascontrol
study.Nineteen
healthy group.砀e
ofGhrelinin mucosaWasdetermined
expression gastric by
staining.
in
Results(!)TheofGhrelin mucosaof withlivercirrhosis
expression gastric patients
Waslowerthanthatinthecontrol theinfectionrateofHelicobacter
group(pO.05),but
withlivercirrhosisWas thanthatin
pylori(H.pylori)of thecontrol
patients higher
ofGhrelinin mucosaofchronic
group(pO.05).②Theexpression gastric HBV-infected
Waslowerthanthatinthecontrol
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