是否对肝脏缺血再灌注损伤的双重作用,通过活化NF-κB的反馈.pdfVIP

Research Article PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-jB 1,2, 1,2, 1,2 1,2 3 1,2 Jiajie Hou , Yongxiang Xia , Runqiu Jiang , Dianyu Chen , Juan Xu , Lei Deng , Xingxu Huang3,⇑, Xuehao Wang1,2,⇑, Beicheng Sun1,2,⇑ 1State Key Laboratory of Reproductive Medicine and Liver Transplantation Center of the First Affiliated Hospital, Nanjing Medical University, 2 3 Nanjing, Jiangsu Province, PR China; Jiangsu Key Laboratory of Xenotransplantation, Nanjing, PR China; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, PR China Background Aims: Nuclear factor-jB (NF-jB) activation in Introduction hepatocytes and macrophages appeared as a double-edged- sword in hepatic ischemia reperfusion (IR) injury. Protein tyro- Hepatic ischemia reperfusion (IR) injury, a frequent and inevita- sine phosphatase receptor type O (PTPRO) was recently identified ble problem during liver transplantation, resection, hemorrhage, as a potential activator of c-Src, which can in turn activate the etc., causes significant limitations to the clinical outcome of liver NF-jB pathway. In this study, we aimed to determine the change surgery. IR associated liver damage is mediated by numerous and function of PTPRO in hepatocytes and macrophages during molecules