结直肠腺癌患者血清IGF1和IGFBP3的变化及其临床意义.pdfVIP

factorfactorin—like SerumIGF．1and incoiorectaladenomaandtheir IGFBP．3 clinical significance Abstract the ofserumIGF·-1andIGFBP··3incolorectal Objective：Toinvestigateexpression adenomaandtheirclinical significance． with Methods：Bloodobtainedfrom120 eolorectal samples patients adenoma(CRA)，48 andIGFBP-3were withcolorectal 34 IGF一1 cancer(CRC)andcontrols，Serum healthy with measured immunoradiometric assayORMA)， radioimmunoassay(RIA)and respectively． IGF一1and inCRC IGF—lhGFBP一3 Results：Serum CRA controls group(224．75__+69245；0．055+0．010)，andhealthy group(195．39+63．37； 0．047+_0．01 theformertwo were 3)werereducinggradually，and groupssignificantly withthelast wasno difference highercompared group(P0．05)．Theresignificant betweenseruln inCRAandclinical IGF·1，IGFBP-3，IGF一1／IGFBP-3 pathology， and of cancer,the includinggender,age，smokingdrinking，familyhistory size，number， siteand classificationof IGF-1andIGF-lflGFBP一3inCRC histological polyps．Serum CRA 1±73．72；0．056_+ group(247．35±60．77；0．063±0．OlO)，high—riskgroup(235．8 CRA 0．0“)，advanced grou