三维适形放疗联合介入化疗治疗局部晚期胰腺癌的临床观察.pdfVIP

JOURNALOFBASICAND CLINICALONCOLOGYVo1．27No．2Jun．2014 三维适形放疗联合介入化疗 治疗局部晚期胰腺癌的临床观察 舒建山，易峰涛，张 帆，邵志雄，宋青玲，徐振华，曾 程 (广州军区武汉总医院肿瘤微创科 ，湖北 武汉 430070) [摘要]目的 评价三维适形放疗联合介入化疗对局部晚期胰腺癌的治疗效果。方法 将46例局部晚期 胰腺癌患者分为2组 ，对照组 18例仅采用三维适形放疗，观察组28例采用三维适形放疗 +介入化疗。结果 观察组有效率、生存、临床受益反应均优于对照组(P0．05)，2组毒副反应比较差异无统计学意义(P 0．05)。结论 三维适形放疗联合介入化疗治疗局部晚期胰腺癌具有较好的近远期疗效，且耐受性好。 [关键词]胰腺癌；三维适形放疗 ；介入化疗 DOI：10．3969／j．issn．1673-5412．2014．02．011 [中图分类号]R735．9；R730．58 [文献标识码]A [文章编号]1673—5412(2014)02—0124—03 Three-dimensionalConformalRadiotherapyCombinedwith Interventional ChemotherapyintheTreatmentofLocallyAdvancedPancreaticCancer ShuJianshan，YiFengtao，ZhangFan，ShaoZhixiong，SongQingling，XuZhenhua，ZengCheng (DepartmentofMinimalInvasiveTumorTherapyCenter， WuhanGeneralHospitalofGuangzhouCommand，Wuhan430070，China) [Abstract]Objective Toevaluatetheefficacyofthree—dimensionalconformalradiotherapycombinedwithinter— ventional chemotherapyinthetreatmentoflocallyadvancedpancreaticcancer．M ethods Forty—sixpatientswithlo— callyadvancedpancreaticcancerweredividedintotwogroups，18patient ofthecontrolrgoupreceivedthree—di— mensionalconformalradiotherapy，and28patientsoftheobservationrgoupithree—dimensionalconformalradiothera— PYcombinedwithinterventionalchemotherapy．Results Theresponserate，：survivalandclinicalbenefitresponseof theobservationrgoupwerebetterthanthoseofthecontrolrgoup(P0．05)；therewasnostatisticaldifferencein thetoxicitiesbetweenthetworgoups(P0．05)．Conclusion Three—dimensionalconformalradiotherapycorn— binedwithinterventionalchemotherapyiseffectandsafeinhtetreMme~ of pmiemswithlocallyadvancedpancreat- iccancer．