膜乳化和微流控法制备单分散W_O乳液的研究.pdfVIP

2009 年37 卷第2 期 · · 广州化工 63 科学实验 膜乳化和微流控法制备单分散W/O 乳液的研究* 任平伟，褚良银 （四川大学化学工程学院，四川 成都 610065） 摘 要：以油相为连续相、水相为分散相，分别采用SPG膜乳化法和微流控技术制备出了单分散W/O乳液。对两种制备 单分散乳液的方法进行了系统比较。结果表明，微流控技术不仅更易操作，而且制备出的W/O乳液单分散性更好。 关键词：SPG膜乳化法；微流控技术；单分散；W/O乳液 Preparation of Monodisperse Water-in-Oil Emulsions Using Membrane Emulsification and Microfluidic Emulsification Methods* REN Ping-wei, CHU Liang-yin （School of Chemical Engineering, Sichuan University, Sichuan Chengdu 610065, China） Abstract ：Monodisperse water-in-oil emulsions were prepared successfully by using Shirasu Porous Glass (SPG) membrane emulsification and microfluidic emulsification. In the preparation, kerosene containing 8 % (w/v) PGPR 90 was used as continue phase, and deionized water as dispersed phase. The comparison results showed that the emulsions prepared by the microfluidic emulsification were more monodisperse than those prepared by SPG membrane emulsification. Furthermore, the emulsification method using the microfluidic device was much easier to operate than that using the SPG membrane. SPG Key words ： membrane emulsification; microfluidic device; monodisperse; w/o emulsion 乳液，是一种液体分散在互不相溶的另外一种液体里的 1 实验部分 混合物。被分散的液体称为分散相，另一种液体则称为连续 1.1 试剂和仪器 相。油包水乳液（W/O）则是一种分散相为水相、连续相为油 煤油, 成都四通化学试剂有限责任公司；去离子水， [1~3] [4] [5] 相的乳液，广泛应用于药物的控制释放 、化妆品 、食品 以 Milli-Q；聚甘油蓖麻醇酸 [6] 及其它化工行业中 。在这些应用之中，W/O乳液的单分散性 管式膜，Miyazaki，Japan，经辛基—三乙氧机硅烷和聚甲基硅 置关重要。如在药物控制释放方面，以含活性单体的W/O乳