奥曲肽联合奥美拉唑治疗肝硬化上消化道出血的临床观察.pdfVIP

· 药物与临床一 一 ～一 2009年12月第47卷第34期 奥曲肽联合奥美拉唑治疗肝硬化上消化道出血的临床观察 陈红莲 孙有利 (漯河医学高等专科学校第三附属医院，河南漯河462000) 摘【要1目的 探讨奥曲肽联合奥美拉唑治疗肝硬化上消化道出血的临床疗效。方法 将60例患者随机分为观察组和对照组 各30例，观察组应用奥曲肽联合奥美拉唑治疗，奥曲肽先予0．1mg静脉推注，然后以25 g，h持续静脉滴注48～72h；奥美 拉唑40mg加人生理盐水 lOOmL静脉滴注持续48 72h。对照组使用垂体后叶素，先予20U静脉推注，然后以15Uh／微泵维 持48 72h；观察各组的止血效果。结果 观察组治疗总有效率为93．33％，高于对照组的56．67％，差异具有显著性(P 0．O1)。结论 奥曲肽联合奥美拉唑是治疗肝硬化上消化道出血的有效措施之一 ，副反应小，值得临床推广。 关【键词】奥曲肽；奥美拉唑；垂体后叶素；上消化道出血；肝硬化 冲 图分类号】R975；R573．2；R575．2 [文献标识码】A 文【章编号】1673—9701(2009)34—40—02 Combination of Octreotide and Om eprazole in Treatment of Liver Cirrhosiswith Upper GastrointestinalHemorrhage CHEN Hongtian SUN I TheThird Affiliated HospitalofLuohe MedicalCollege，Luohe462000，China IAbstract】ObjectiveToexplorethecurativeeffectofoetreotidecombinedwithomeprazoleinthe~eatmentofuppergastrointestinal hemorrhage in livercirrhosis．MethodsSixtylivercirrhosispatientswith uppergastrointestinalhemorrhagewere dividedrandomLy into observationgroup(30cases)nadcontrolgroup(30eases)．Theobservationgroupwastreatedwithoetreotidenadomeprazole，firstinrtavenous bolusinjectionofoetreotide0．1mgofllowedbycontinuousintravenousinfusionofoetreotide25 g／hfor48-72h，andhtencontinuous intravenousinfusion ofomeprazole40mg for48-72h withadditionofnormalsaline lOOmL．Thecontrolgroupwastreated tIlpimitrin． firstintravenousbolusinjectionofpituitrin20Unadthenintravenousinfusionofpituitfin 15Uh／wiht amicro—pumpfor48～72h．The hemostaticeffcetineachrgoupwasobserved．ResultsThetotaleffectiverateoftheobservationrgoup(93．33％)Wasbe~erhtanhtatof htecontrolgroup(56．67％)，withasignificnatdifferencebetweenthetworgoups(P0．01)．ConclusionThecombineduseofoctreotide nad omeprazoleiseffectivein the treatmentofuppergastrointestinalhemorrhage in livercirrhosis，with few sideeffects，worthyofbeing