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BMC Cancer BioMed Central
Research article Open Access
Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1,
CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer
risk
† †
Lara Bethke , Emily Webb , Gabrielle Sellick, Matthew Rudd,
Stephen Penegar, Laura Withey, Mobshra Qureshi and Richard Houlston*
Address: Section of Cancer Genetics, Institute of Cancer Research, Surrey, UK
Email: Lara Bethke - lara.bethke@icr.ac.uk; Emily Webb - emily.webb@icr.ac.uk; Gabrielle Sellick - gabrielle.sellick@icr.ac.uk;
Matthew Rudd - matthew.rudd@icr.ac.uk; Stephen Penegar - stephen.penegar@icr.ac.uk; Laura Withey - laura.withey@icr.ac.uk;
Mobshra Qureshi - mobshra.qureshi@icr.ac.uk; Richard Houlston* - richard.houlston@icr.ac.uk
* Corresponding author †Equal contributors
Published: 5 July 2007 Received: 23 June 2006
Accepted: 5 July 2007
BMC Cancer 2007, 7:123 doi:10.1186/1471-2407-7-123
This article is available from: /1471-2407/7/123
© 2007 Bethke et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer
(CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex
hormones.
Methods: To inves
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